Nothing can speak to the experience you'll encounter with BioTek like stories from our customers themselves. Customer satisfaction is our top priority. From Engineering to Manufacturing to Sales and Support, BioTek employees around the world are dedicated to providing the best product and best customer experience in the industry.
Dr. Jorge Farías Avendaño, Universidad de La Frontera, Temuco, Chile
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Dr. Jorge Farías studies cellular and molecular mechanisms in fish spermatozoa as part of his role as the Director of Chemical Engineering at the Universidad de La Frontera in Temuco, Chile. Spermatogenesis, which is the development of sperm, is a delicate balance between cell proliferation, differentiation and apoptosis, and disruptions can have profound implications.
Kirk McManus, Associate Professor, University of Manitoba, and Senior Scientist, CancerCare Manitoba, discusses his ground breaking colorectal cancer research, which aims to minimize the morbidity rates of cancers. Learn how this research is being carried out using an advanced instrument workflow from BioTek, which has streamlined his team's cancer cell studies to great effect.
Department of Immunobiology, University of Arizona College of Medicine
Related Products: Cytation 5
Metals play a very important role in biology, as metal ions are associated with an estimated 40% of all proteins. In bacteria, dedicated acquisition and efflux systems tightly control metal homeostasis. Some metals, such as iron, are so critical to bacterial physiology that in most cases only the acquisition system exists; while others, such as copper, are so toxic that only efflux systems exist. It is this copper toxicity that is of particular interest to Dr. Michael Johnson and his new laboratory in the Department of Immunobiology at the University of Arizona’s College of Medicine. Dr. Johnson notes that although bacteria can develop resistance, as seen against modern antibiotic therapies, they remain vulnerable to the toxic effects of copper. His research aims to unravel this age-old mystery by understanding how copper is toxic to bacteria, and how bacteria overcome copper toxicity.
Amila Nanayakkara, a researcher in the laboratory of Dr Pia Vogel and Dr John Wise in the Department of Biology at the Southern Methodist University of Dallas, spoke to SelectScience® about the lab’s techniques and technologies and how they are used to advance their cancer research.
Tumor Chemosensitivity Laboratory (LQT), University of Costa Rica
Related Products: Cytation 3
Malignant tumors are heterogeneous, demonstrating a diverse population of cell morphologies and phenotypic profiles. This results in specific cancer types expressing dissimilar characteristics from one patient to the next, and chemotherapies targeted towards a specific tumor may not eradicate the entire cellular mass. Dr. Steve Quiros and his colleague, Dr. Rodrigo Mora, at the Tumor Chemosensitivity Laboratory (LQT), Faculty of Microbiology at the University of Costa Rica are taking a close look at mechanisms to circumvent these hurdles and increase the effectiveness of chemotherapies, cancer diagnostic tools and personalized treatments.
With more than a decade of experience, few researchers have more expertise than Dr. Sachin Katyal when it comes to the comet assay, also known as single cell gel electrophoresis (SCGE). As a post-doc at St. Jude Children’s Research Hospital, Dr. Katyal incorporated this assay to study neural damage, and now in his dual role as Assistant Professor in Pharmacology and Therapeutics at the University of Manitoba and Senior Scientist with the Research Institute in Oncology and Hematology (RIOH) at CancerCare Manitoba in Winnipeg, Canada, Dr. Katyal applies the comet assay in his studies on brain tumors and other cancers.
AssayQuant Technologies, Inc.
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AssayQuant Technologies, Inc., in Marlborough, Massachusetts is a growing Life Science company that develops innovative enzyme assay formats for a quantum improvement in performance and productivity to enable discovery or accelerate drug development. Its founders, Dr. Erik Schaefer and Dr. Barbara Imperiali, each impart a wealth of experience that allows AssayQuant to deliver exceptional value to their customers.
Dr Kirk McManus, Associate Professor in the Department of Biochemistry & Medical Genetics at the University of Manitoba and a Senior Scientist within the Research Institute in Oncology at CancerCare Manitoba, spoke to SelectScience® about his cutting-edge cancer research, which aims to identify cancer causing genetic abnormalities and screen potential therapies.
National University of Science and Technology
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In the Department of Environmental Science and Health at the National University of Science and Technology (NUST) in Bulawayo, Zimbabwe, Mr. Charles Teta specializes in ecotoxicology. His research includes uncovering the frequency and effects of endocrine disrupting chemicals in native fish, and analyzing hazardous chemicals such as heavy metals and pesticides in the environment that may have originated from municipal landfills, mines and urban effluents. With several kinetic and end-point assay techniques already employed, the manual processes were time consuming, and human error was an ever-present risk when dispensing into a microplate with a single-channel or multi-channel pipette. If reagents were added too slowly, or mixed incompletely, the assays had to be repeated, thereby doubling efforts, sample volume and costly materials.
Beckman Research Institute at City of Hope National Medical Center
Related Products: Cytation 3
In the Department of Immuno-Oncology in the Beckman Research Institute at City of Hope National Medical Center, Dr. Marcin Kortylewski and his group incorporate a “flank” strategy in the fight against cancer. Instead of directly focusing on tumor cells, which can evolve over time, the researchers target well-defined immune cell functions. Dr. Kortylewski explains that the immune cell protein, STAT3 (signal transducer and activator of transcription, third member of the family), plays the role of master regulator for normal immune response. STAT3 also performs a similar function when immune cells migrate into the tumor microenvironment. This creates an immunosuppressive effect that prevents a strong anti-tumor response, so blocking this protein can re-energize anti-tumor immunity. His research suggests that oligonucleotide-based therapeutics that inhibit STAT3 in a cell-selective manner may effectively restore the anti-tumor immune response.
Related Products: Cytation 5
Watch this video to learn more about the drug and product screening process at Likarda, a contract research organization. Dr Lisa Stehno-Bittel, President & CEO of Likarda, discusses the problems of screening drugs for efficacy. Due to the nature of cultured cells, it is very difficult to predict which drugs you’re working with are finally going to work in the human body. By employing the BioTek Cytation 5, Likarda is able to offer the most sophisticated 3D results, efficiently testing drugs in a representative manner.